CCL17-producing cDC2s are essential in end-stage lupus nephritis and averted by a parasitic infection
نویسندگان
چکیده
منابع مشابه
Lupus nephritis and end-stage kidney disease.
Systemic lupus erythematosus (SLE) is a multisystem disease affecting many organs. Varying degrees of renal involvement are seen in up to 60% of adults with SLE, and severe lupus nephritis (LN) (World Health Organization class III and above) progresses to end-stage kidney disease (ESKD) within 15 years of diagnosis in 10% to 30% of patients. In fact, renal injury is the most important predictor...
متن کاملtreatment algorithm for the prevention of end-stage renal disease in children with lupus nephritis
chronic kidney disease is one of the most common complication of systemic lupus erythematosus, which if untreated can lead to the end-stage renal disease (esrd). early diagnosis and adequate treatment of lupus nephritis (ln) is critical to prevent the chronic kidney disease incidence and to reduce the development of esrd. the treatment of ln has changed significantly over the past decade. in p...
متن کاملDialysis and Pregnancy in End Stage Kidney Disease Associated with Lupus Nephritis
Female patients with systemic lupus erythematosus are often of childbearing age at diagnosis, and though fertility in these patients is similar to the general population, successful pregnancy remains a rare occurrence. This incidence is, however, increasing and the management of these high risk pregnancies is often further complicated by the patient's need for dialysis as a result of lupus neph...
متن کاملLupus Nephritis in Males: Clinical Features, Course, and Prognostic Factors for End-Stage Renal Disease
Introduction Because of their rarity in men, systemic lupus erythematous and lupus nephritis (LN) are poorly understood in men. Our aim was to analyze the clinical presentation and course of histology-proven systemic lupus erythematous and LN in males and to determine the risk factors for progression to end-stage renal disease. Methods Fifty patients from 2 historical cohorts in Spain (Hospit...
متن کاملThe prognosis of lupus nephritis in children
Introduction: Lupus nephritis is a systemic disease which affects different organs. The present study was designed to review lupus nephritis, in children its outcome and the related factors. Methods: We reviewed 48 children with lupus nephritis. Clinical and epidemiological features were studied. The patients’ outcomes and related factors were analyzed. Patient and renal survival rate were ca...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2021
ISSN: 1558-8238
DOI: 10.1172/jci148000